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pentobarbital will minimize the extent or impact of flurbiprofen by impacting hepatic enzyme CYP2C9/10 metabolism. Small/Importance Unfamiliar.pentobarbital decreases amounts of elvitegravir/cobicistat/emtricitabine/tenofovir DF by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Could result in loss of virologic reaction and